Preheat oven to 375 degrees.
Bring a large pot of water to a rolling boil. Cook pasta for one minute less than package directions state.
While the pasta is cooking, melt 3 tablespoons of butter in a medium sized pot and add the flour. Cook, whisking constantly, over low heat for 2 minutes.
Continue whisking and slowly pour in the milk and cream. Cook for another 2 minutes until thickened and smooth.
Remove from the heat and stir in the cheddar, gruyere, cream cheese, salt, pepper, and nutmeg. Continue stirring until the cheese has melted and the sauce is smooth. Return to low heat in short bursts if needed to melt the cheese fully.
Drain the pasta and add to the cheese sauce. Stir to coat. Pour mixture into a buttered 2 quart baking dish.
Melt the remaining 2 tablespoons of butter and mix it with the Panko, Parmesan cheese, and garlic powder.
Sprinkle the bread crumbs evenly over the mac and cheese.
Bake for 25 minutes or until the sauce is bubbly and the bread crumbs are browned and crispy.