Preheat the oven to 475 degrees and line a baking sheet with foil.
Mix together the salt, garlic powder, pepper, and onion powder in a small bowl. Coat the meat in the spice mixture and place the meat on the prepared baking sheet.
Roast at 475 degrees for 20 minutes.
Reduce heat to 275 and continue cooking until meat reaches the desired temperature (about 40 more minutes for medium rare, 60 minutes for medium, 80 minutes for well done).
Remove meat from the oven and tent with foil and allow to rest for 30 minutes.
Slice as thin as possible using a sharp knife or meat slicer.
Store in a sealed bag in the fridge for up to one week or in the freezer for 6 months and thaw in the fridge as needed.