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Cajun chicken Alfredo in skillet.

Cajun Chicken Alfredo

Rich and creamy Alfredo sauce is a breeze to make. We've spiced it up with juicy chicken and Cajun flavors for a quick weeknight meal that our entire family loves.
Course Main Course
Cuisine Cajun
Keyword easy pasta recipes, easy recipes, weeknight dinner recipes
Prep Time 10 minutes
Cook Time 30 minutes
Total Time 40 minutes
Servings 6 servings
Calories 878kcal


  • 1 pound boneless, skinless chicken breasts
  • 2 teaspoons Cajun seasoning plus more, to taste
  • 1 tablespoon olive oil
  • 16 ounces fettucine
  • 1/2 cup butter
  • 2 cloves garlic minced
  • 1 cup heavy cream
  • 8 ounces shredded Parmesan
  • 4 ounces shredded mozzarella


  • Pound the chicken breasts to an even thickness. Season with the Cajun seasoning, making sure to coat both sides of the chicken.
  • Bring a large pot of salted water to a boil.
  • Heat a large oven proof skillet over medium heat. Swirl in the oil to coat the pan.
  • Add the chicken to the skillet and cook through, flipping halfway through cooking, about 10 minutes.
  • Remove the chicken from the skillet and place on a cutting board to rest.
  • Add the fettucine to the boiling water and cook until al dente.
  • While the pasta is boiling, place the skillet back over medium heat and add the butter. Once melted, stir in the garlic and cook for about 30 seconds.
  • Add the heavy cream to the skillet and cook for 2-3 minutes to heat the cream. Once hot, add the cheeses and whisk together until the sauce is smooth and combined.
  • Taste and season with Cajun seasoning, as desired.
  • Drain the pasta and add it to the sauce. Toss to coat.
  • Slice or chop the chicken and serve with the pasta.



Some Cajun seasoning blends are very salty. Taste as you go and season to taste.


Calories: 878kcal | Carbohydrates: 57g | Protein: 46g | Fat: 52g | Saturated Fat: 29g | Polyunsaturated Fat: 3g | Monounsaturated Fat: 16g | Trans Fat: 1g | Cholesterol: 248mg | Sodium: 978mg | Potassium: 567mg | Fiber: 3g | Sugar: 2g | Vitamin A: 1877IU | Vitamin C: 1mg | Calcium: 607mg | Iron: 2mg