Preheat oven to 350 degrees. Line a 9x13 baking dish with parchment paper or foil and spray with non-stick cooking spray.
In a small bowl, combine the Oreo crumbs and melted butter to combine. Press the mixture into the prepared baking dish.
Top with the Reese’s Minis, pretzels, chocolate chips, and peanut butter chips, in that order. Pour the sweetened condensed milk over the top. Sprinkle on the Reese’s Pieces evenly.
Bake for 25 minutes or until golden brown and bubbly. Let cool for at least 2 hours before cutting and serving.